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Can Hydrocodone Cause Heart Attack

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Do Opioids Hurt Your Heart Over Time

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Research suggests that taking opioids for an extended time could take a toll on the heart. A study by the Vanderbilt Department of Health Policy examined the effects of long-acting opioids on patients taking them for pain. Compared to patients who took non-opioid painkillers, patients who took opioid medications had a 65 percent higher chance of cardiovascular death. The researchers theorized that opioids effect on nighttime breathing had an impact on their heart health.

What Should I Discuss With My Healthcare Provider Before Taking Acetaminophen And Hydrocodone

You should not use this medicine if you are allergic to acetaminophen or hydrocodone, or if you have:

  • severe asthma or breathing problems or
  • a blockage in your stomach or intestines.

Tell your doctor if you have ever had:

  • breathing problems, sleep apnea
  • liver disease
  • a head injury or seizures
  • urination problems or
  • problems with your thyroid, pancreas, or gallbladder.

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

Ask a doctor before using opioid medicine if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

Ibuprofen May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:

  • constipation
  • confusion
  • aggression

Ibuprofen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .

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Common Illicit Drugs Associated With Adverse Effects On Cardiovascular Disease

Illicit drugs are banned from commercial sale and trade in many countries. This is due to the side-effect profile, addiction potential, often-high tolerance profiles and potential for dependence that are disproportional to those acceptable to several regulatory and drug-approval authorities worldwide. These properties may increase the risk of abuse of these drugs over time.

Illicit drugs, also often referred to as drugs of abuse, may provide subjectively positive effects initially, but become the basis for habit formation, addiction, physiological or psychological dependence and unpleasant withdrawal over time. Their use may also lead to emotional and behavioral abnormalities, to the extent of the onset of personality change or psychoses. The chronicity of these changes may be related to the length, or extent of abuse.

In some cases, these drugs may have been available as therapeutic commercial products in the past. However, a combination of socially unacceptable abuse, safety concerns and other socioeconomic factors have driven them into disrepute and prohibition from widespread use. These drugs are associated with the increased risk of many conditions and adverse events including a myriad of cardiovascular disorders. The use of some drugs may also be related to deteriorations and increased mortality in those with pre-existing cardiovascular disease. For example, one in five adults aged 18 to 44 who had experienced a stroke in 2005 had abused illicit drugs21.

What Should I Avoid While Taking Acetaminophen And Hydrocodone

Can I Take Ibuprofen With Hydrocodone Acetaminophen

Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Do not drink alcohol. Dangerous side effects or death could occur.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen . Taking certain medications together can lead to a fatal overdose.

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The Use Of Opioids In Medicine

Opioids are especially useful for controlling severe pain caused by temporary medical conditions, such as broken bones or post-operative pain, and in controlling pain associated with severe end-stage medical problems, especially terminal cancer. In these situations, opioids tend to be very effective, and the risks associated with using them is minimal.

They can also be effective in treating less severe and more chronic pain, but their usage for this type of pain is very controversial. Chronic usage of opioids may lead to abuse and addiction. This is partly related to the fact that opioids display the feature known as tolerancethat is, over time people need higher and higher doses of opioids to achieve the same levels of pain control that were initially achieved with much lower doses. Prescribing and taking the right amount of opioids for long periods of time, therefore, is a challenge.

Experts recommend that when opioids are used to treat chronic pain not associated with cancer, their use be supervised by doctors who specialize in pain control.

Several opioids are currently used in medical care, including buprenorphine, codeine, fentanyl, Oxycontin, methadone, morphine, Percocet, and Vicodin.

Do Chronic Opioids Worsen Cardiac Outcomes

Few studies have been published evaluating the effect of chronic opioids on cardiac outcomes. Carman et al. published a retrospective claims-based study that evaluated the incidence of myocardial infarction, or MI associated with coronary revascularization, among individuals taking chronic opioids at high doses vs low doses, and compared with cohort from general population with otherwise similar risk stratification . This evaluation included 148,657 people in both the chronic opioid group and the control group. When the incidence rate ratios were adjusted for coronary heart disease risk factors, the risk for MI was 2.7 times higher and the risk for MI/CR was 2.4 times higher in patients taking chronic opioids when compared with the matched controls. The study included a third group of 64,072 chronic users of celecoxib and 20,502 chronic users of valdecoxib. These COX-2 selective nonsteroidal anti-inflammatory drug users had 1.71.9 times the rate of MI and MI/CR when compared with the controls. Therefore, this study reported that the increased risk for myocardial infarction is higher in patients consuming chronic opioid than that observed in patients taking chronic COX-2 selective nonsteroidal anti-inflammatory drugs.

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What Should I Discuss With My Healthcare Provider Before Taking Hydrocodone And Ibuprofen

Ibuprofen can increase your risk of fatal heart attack or stroke, even if you don’t have any risk factors. Do not use this medicine just before or after heart bypass surgery .

Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

You should not use this medicine if you are allergic to hydrocodone or ibuprofen , or if you have:

  • severe asthma or breathing problems or
  • a stomach or bowel obstruction .

Tell your doctor if you have ever had:

  • breathing problems, sleep apnea
  • problems with your gallbladder, pancreas, or thyroid
  • urination problems or
  • drug or alcohol addiction, or mental illness.

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with hydrocodone and cause a serious condition called serotonin syndrome.

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks. Taking ibuprofen during late pregnancy may cause bleeding in the mother or the baby during delivery.

You should not breastfeed while using this medicine.

How Opioid Use Can Cause Heart Problems

What causes a heart attack?

Opioid use can have many damaging effects on the heart. These drugs are central nervous system depressants. This means they slow down most bodily functions. The cardiac effects of opioid abuse can include bradycardia, a condition involving the slowing of ones heart rate, and vasodilation, or decreased blood pressure.

Pain Medicine explains that this slowed heart rate and decreased blood pressure can lead to any of the following:

  • Dangerously low blood pressure
  • Excess fluid in the body
  • Loss of consciousness resulting from lack of blood flow to the brain 2

Prolonged opioid abuse can also cause QT syndrome, a heart defect that slows the electric conduction of the heart. This disrupts the hearts regular rhythm. Even short-term opioid abuse can disrupt the hearts normal rhythm to cause heart palpitations and arrhythmias. Long-term opioid abuse can cause a permanent delay in heart rhythm, which can result in heart damage and poor oxygen delivery. Long-term opioid use can also lead to infections of the heart lining and valves.

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What Is The Most Important Information I Should Know About Hydrocodone And Ibuprofen

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Ibuprofen can increase your risk of fatal heart attack or stroke. Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal.

How Do Opioids Impact Your Hearts Health

Depending on your situation and health conditions, opioids can have the following effects on your heart:

  • Slow heart rate : Taking opioids can cause your heart rate to slow down in a symptom called bradycardia. Opioids slow down the sinus node responsible for regulating the hearts electrical signals. Bradycardia usually doesnt cause symptoms, but it can make exercise more difficult.
  • Fast and irregular heart rhythm : Opioid medications can also disrupt the electrical signals in the atria, your hearts upper cardiac chambers. This disruption results in a rapid and irregular heart rhythm known as atrial fibrillation. Atrial fibrillation raises a persons risk of heart attack and stroke.
  • Dilated blood vessels : Some people who take opioids experience vasodilation, the widening of the blood vessels. Vasodilation can cause low blood pressure. Severely low blood pressure can deprive your heart and brain of the oxygen they need to function.
  • Heart infection : People who misuse injected opioids like heroin have an increased risk of infectious endocarditis. This heart infection involves vegetations that consist of bacteria, platelets and protein that can block blood vessels.

An opioid medication can also reduce your heart muscles function when you take it with a benzodiazepine. This category of drugs includes medications like Valium® that treat anxiety, seizures and insomnia. Remember to tell your doctor about all of the medicines you take before receiving an opioid prescription.

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Cough And Cold Medications

Many of these medications contain NSAIDs to relieve pain. They also often have in them, which can make your heart disease worse in these ways:

Ask your doctor about other ways to ease symptoms of cold, flu, or sinus problems.

What Should I Know About Storage And Disposal Of This Medication

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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture .

It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.

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How Nsaids Harm The Heart

NSAIDs pose a risk to the cardiovascular system for two main reasons. First, they change levels of substances in the blood that make clots more likely. A blood clot can block a narrowed artery in the heart, triggering a heart attack. Second, NSAIDs change blood flow in the kidneys, causing the body to retain more salt and water, explains Dr. Antman. That causes blood pressure to rise, which also boosts the risk of a stroke. High blood pressure also makes people more prone to atrial fibrillationa rapid, quivering motion of the heart’s upper chambers.

In fact, a recent study found a higher risk of atrial fibrillation in people who had taken NSAIDs during the past 15 to 30 days compared with people who had never taken NSAIDs.

Substance Abuse & The Heart

Substance abuse is defined as the excessive and/or compulsive intake of a compound that can cause changes in the neurological or biochemical state of an individual. This may be associated with physiological and/or psychological dependence on the compound in question. This intake is categorized as abuse when it leads to significant impairments in the ability to function in occupational and/or societal terms. Substance abuse may lead to deteriorations in existing health complaints, or to the need for treatment for complaints that may have arisen due to substance abuse1. This abuse may be strongly associated with some conditions such as infective disease2.

The ingestion of harmful substances, particularly drugs and alcohol, may be associated with deterioration in the health of the heart and/or blood vessels3. This is known as cardiovascular disease, and may have considerable impacts on overall health and longevity. This guide will discuss the potential roles substance abuse may play in the risk of cardiovascular disease, and the potentially harmful effects of dangerous ingestible substances on pre-existing disorders of the vascular system.

If you believe you or someone you love may be struggling with a substance abuse issue that could be impacting their health, call our addiction hotline today at to discuss your options and reclaim your life.

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What Other Information Should I Know

If you are taking prescription ibuprofen, do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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How Should This Medicine Be Used

Prescription ibuprofen comes as a tablet to take by mouth. It is usually taken three or four times a day for arthritis or every 4 to 6 hours as needed for pain. Nonprescription ibuprofen comes as a tablet, chewable tablet, suspension , and drops . Adults and children older than 12 years of age may usually take nonprescription ibuprofen every 4 to 6 hours as needed for pain or fever. Children and infants may usually be given nonprescription ibuprofen every 6 to 8 hours as needed for pain or fever, but should not be given more than 4 doses in 24 hours. Ibuprofen may be taken with food or milk to prevent stomach upset. If you are taking ibuprofen on a regular basis, you should take it at the same time every day. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ibuprofen exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.

Ibuprofen comes alone and in combination with other medications. Some of these combination products are available by prescription only, and some of these combination products are available without a prescription and are used to treat cough and cold symptoms and other conditions. If your doctor has prescribed a medication that contains ibuprofen, you should be careful not to take any nonprescription medications that also contain ibuprofen.

What Do I Do If I Miss A Dose

  • If you take this drug on a regular basis, take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • Many times this drug is taken on an as needed basis. Do not take more often than told by the doctor.

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How The Opioid Crisis Is Hitting Cardiology

The opioid epidemic in America continues to be a national crisis. In2017, a persons likelihood of dying from an opioid overdose exceeded the riskof dying in a motor vehicle crash for the first time in history. The NationalInstitute on Drug Abuse reports that more than 130 people die every day fromoverdose. In states with the highest death rates from drug overdoses, thenumber of deaths from drug overdose were five times higher than the number ofalcohol-related deaths and approximately three-times higher than suicide rates.

As high as twenty percent of people taking prescription painmedication will develop an addiction and 45 percent of heroin users startedwith a prescription opioid addiction. All sectors of the healthcare system arefeeling the effects of the opioid crisis, with more recent attention beingdrawn to cardiology.

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