Use Of Benadryl While Pregnant
Allergies are pretty common during pregnancy. It is reported that 20-30% of women who are of childbearing age are affected by allergies, and in a subset of women, pregnancy can even aggravate some preexisting allergy symptoms such as allergic rhinitis. As a result, antihistamine drugs are often employed to treat these allergic symptoms. This gives birth to a question of whether the use of antihistamines or specifically Benadryl while pregnant is safe?
Although alternative methods, such as fluids and rest, should be attempted first to treat the; symptoms of allergies during pregnancy. First-generation antihistamines like Diphenhydramine are drugs of choice, especially during the first trimester, for the relief of allergy symptoms in pregnant women. The U.S. Food and Drug Administration lists Benadryl as category B, which means that the drug has failed to demonstrate a risk of birth defects or congenital anomalies to the fetus in animal reproduction studies but there are no adequate and well-controlled studies in pregnant women, OR, animal studies have shown adverse effects, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk of birth defects or anomalies to the fetus in any trimester.
The Faster The Heart Rate The Shorter The Lifespan
True: In a large study of people going for a health checkup in China, those who had a high-normal resting heart rate of 80 bpm to 90 BPM had a 40 percent shorter lifespan than those with a desirable heart rate of 60 BPM to 69 BPM.
However, the good news is that 15 minutes to 30 minutes of daily moderate exercise, such as brisk walking, could eliminate the increased mortality and reverse the life-span loss, the researchers say.
The study underlines;the important role that;physical activity can play in keeping your heart healthy and giving you a longer life, Dr. Laffin says.
Even moderate activity has benefits, he says. So there is no longer any reason to stay on the couch.
Melatonin And Cardiac Diseases
Melatonin induces multiple actions in various cardiac pathologies . In this paper, only relevant evidence in myocardial infarction, myocardial ischemia/reperfusion injury and heart failure is included .
Table 1. The effect of melatonin supplementation on cardiac diseases: animal studies.
Table 2. The effect of melatonin supplementation on cardiac diseases: human studies.
Melatonin supplementation protects the heart in several experimental models of myocardial infarction and myocardial I/R injuries . Tan and co-workers were first to demonstrate the beneficial effects of melatonin in isolated rat hearts subjected to cardiac I/R-induced arrhythmias: infusion of melatonin reduces premature ventricular contraction and ventricular fibrillation due to occlusion and reopening of the anterior descending coronary artery . This finding is also reported in other animal models of cardiac arrhythmias , confirming the therapeutic potential for melatonin in reducing the incidence of sudden cardiac death . Additional studies show that short-and long-term melatonin supplementation is cardioprotective in various in vivo and ex vivo myocardial models of I/R injury . In these studies, administration of melatonin before or after ischemia preserves the microstructure of the cardiomyocyte and reduced myocardial I/R injury as indicated by a reduction in myocardial infarct size .
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Evidence For Cardiovascular Benefits Of Endogenous Melatonin And Melatonin Supplementation
A strong inverse relationship exists between endogenous melatonin levels and cardiovascular disease . Epidemiological studies report that both nocturnal melatonin synthesis and circulating levels are reduced in patients with coronary heart disease , hypertension , heart failure and cardiovascular risk conditions such as diabetes and obesity . Incidence for adverse cardiac events, including myocardial infarction , sudden cardiac death and cardiac arrhythmias increases in the early morning, when circulating melatonin levels are considerably lower . Similarly, low melatonin secretion levels are associated with a greater risk of incidence for myocardial infarction in women with increased body mass index , supporting the crucial role of endogenous melatonin in cardiovascular pathologies.
Solid evidence supports the beneficial effects of melatonin supplementation in various cardiovascular pathologies . Since the cardiovascular benefits of melatonin have recently been reviewed elsewhere , only the evidence for the benefits of melatonin supplementation in hypertension, pulmonary hypertension and ischemic heart disease is summarized below.
Allergy Medicines And Hypertension
Allergy season is in full swing in many parts of the country. For some, that means battling symptoms, such as sneezing, congestion, runny nose, itching, and watery eyes. If you are among the;over 50 million Americans who suffer from allergies each year, you may be headed to a pharmacy near you for relief of your allergy symptoms. Choosing allergy medication that is right for you may be tricky if you have hypertension . Read on to learn how some allergy medicines may affect your blood pressure and your blood pressure medication.
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What Questions Should I Ask My Healthcare Provider
- What type of antihistamine would work best for me?
- How do I proper take the prescribed antihistamine?
- What side effects might occur with the recommended medication?
- What antihistamine wont interfere with the current medications I am taking?
- When, or for what conditions, does taking an antihistamine that would make me drowsy make sense?
- Can I live my life normally while using this medication? Can I drive? Can I operate heavy machinery?
- Can I take antihistamines if I am pregnant, planning to become pregnancy or am breastfeeding?
- Can antihistamines be safely given to my child?
- What are the consequences if I dont take an antihistamine to help with my allergies?
A note from Cleveland Clinic
Histamine is on your side. The chemical does its best to regulate help your heart and lungs and protect your body from foreign allergens, among other roles. But it can be oversensitive, and it can overreact, and thats where antihistamines can help. If youre have allergies, stomach symptoms or any of the other conditions and symptoms mentioned in this article, talk to your healthcare provider about your options. Your symptoms may be able to be treated.
Always check with your healthcare provider and your pharmacist if you have concerns about antihistamines, and always follow the directions on the labels!
Benadryl: Side Effects And Cautions
Benadryl is a well-known antihistamine used to treat allergy symptoms including sneezing, runny nose, and itchy and watery eyes, as well as colds, dry coughs, insomnia, and motion sickness. While typically mild, the side effects of Benadryl may be more intense for some peoplemaking using the drug undesirable, especially during the day, or even unsafe.
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Do Allergy Medicines Interact With My Blood Pressure Medication
Most antihistamines are generally safe to take with your blood pressure medication. However, keep in mind the following drug interactions if you are taking medication for your blood pressure:
- fexofenadine;: Carvedilol may increase the effects of fexofenadine. Use fexofenadine cautiously if you are taking carvedilol.
- cetirizine; and levocetirizine : You may experience increased drowsiness if you take cetirizine or levocetirizine in combination with methyldopa .
- diphenhydramine;: Any product containing diphenhydramine may counteract the effects of many of your blood pressure medications. Be sure to talk with your pharmacist before taking any diphenhydramine products.
Alcohol Use And Benadryl
You shouldnt drink alcohol while youre taking Benadryl. Alcohol can increase your risk of drowsiness or dizziness. It may also cause more serious side effects, such as trouble breathing or slowed breathing.
If you drink alcohol, talk with your doctor about other medications you can take to treat your cold or allergy symptoms.
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What About People With Heart Problems
If you take;medication for high blood pressure and you have a;heart condition, you need;to pay attention if your heart reacts to over-the-counter drugs.
Oftentimes, the heart doctor may overlook this topic because there are so many other things that they must bring to the patients attention, Dr. Kaminski says.
His advice? If you have high blood pressure, atrial fibrillation, supraventricular tachycardia or congestive heart failure, you should avoid OTC medicines that contain a ;.
Dr. Kaminski specifically recommends against using pseudoephedrine.
Can Benadryl Be Used In Babies Or Toddlers If So What Are The Possible Side Effects
Over-the-counter forms of Benadryl shouldnt be used in babies or toddlers. This is because children younger than 6 years old have an increased risk of side effects from Benadryl.
Children can have the same side effects of Benadryl as adults, such as dizziness or drowsiness. But Benadryl can also cause more serious side effects in children, such as a fast heartbeat or seizures. The drug may also cause children to become more excitable or hyperactive.
You should never use Benadryl to help your child fall asleep. This can be very dangerous.
Due to these risks, you shouldnt give Benadryl to your baby or toddler without the direction of their doctor. If your child has symptoms of an allergy or cold, talk with their doctor about the best way to treat those symptoms.
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Do Seniors Have A Higher Risk Of Side Effects From Benadryl
Yes, older adults likely have a higher risk of side effects from Benadryl than younger adults. This is because their bodies may get rid of the drug more slowly.
Older adults may have more side effects from Benadryl, including sleepiness, dizziness, or heart problems. Sleepiness and dizziness can increase the risk of falling, which can be very serious.
If youre an older adult interested in taking Benadryl, talk with your doctor. They may recommend that you take a lower dose of Benadryl to reduce your risk of side effects. Or they may suggest that you take a different medication to treat your allergy or cold symptoms.
Which Allergy Medications Affect My Blood Pressure
You should;avoid decongestants if you have high blood pressure;or heart problems. Decongestants constrict blood vessels to open nasal passages and facilitate breathing. Because decongestants constrict blood vessels throughout your body, they can worsen hypertension. Additionally, decongestants stimulate the release of norepinephrine in your body, which raises your blood pressure and your heart rate.
When choosing an allergy medication, be aware of combination products that contain decongestants. Products that contain a decongestant typically have the words;sinus,;cold,;congestion, or;;on the label. They may also be labeled with the letters;D, PD,;or;PE;after the name.
Examples of allergy medicines that contain decongestants include the following:
- Allegra D
- Benadryl D
- Clarinex D
- Claritin D
- Sudafed Sinus and Allergy
- Zyrtec D
The list above is a small sample of allergy medications that contain decongestants. Always check with your pharmacist before choosing allergy medications.
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Dietary Melatonin And Pulmonary Hypertension
Pulmonary hypertension is associated with an increased oxidative stress and leads to right ventricle hypertrophy and cardiac fibrosis with the hallmarks of the heart failure . A single subcutaneous injection of monocrotaline induces pulmonary hypertension with RV hypertrophy and dysfunction, increase in interstitial fibrosis and plasma oxidative stress . In this model, a chronic dietary melatonin treatment reduces RV hypertrophy, improves RV function, reduces plasma oxidative stress and reduces cardiac interstitial fibrosis, therefore supporting the beneficial effects of curative and preventive treatments of dietary melatonin in pulmonary hypertension . These effects of melatonin are associated with a reduction in oxidative stress and an increase in enzymatic and non-enzymatic antioxidant capacity .
Should Exercisers Lay Off The Antihistamines
Pollen levels are high and you have a 10-K run ahead of you. Do you pop a couple of antihistamines to avoid an allergic reaction? Or not?
Sorry, a definitive answer is not provided here.
However, a newly published study from the UO lab of John Halliwill has raised such questions. The research found that 795 of 3,000 genes activated after vigorous exercise become blunted in their responses during a three-hour recovery period if exercisers had taken strong doses of antihistamines.
Audio: Halliwill’s personal take on using antihistamines during extensive exercise:
Halliwill, a professor in the Department of Human Physiology, discovered in 2005 that naturally occurring histamines in the body relax blood vessels, increasing blood flow that aids post-exercise recovery. That emerged from his original focus on why some people, including athletes, pass out after vigorous physical exertion. He later found a link between an overactivation of two histamine receptors to drops in blood pressure.
The new study led by doctoral student Steven A. Romero and in collaboration with Hans Dreyer, a departmental colleague who studies muscle physiology expanded the research to a wider genetics level. Researchers sequenced RNA, molecules essential for making proteins and sending signals among genes, with state-of-the-art equipment in the UO’s Genomics Core Facility.
The study is now online ahead of print in the Journal of Physiology. The NIH and American Heart Association supported the research.
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Memory Loss Or Dementia
Taking Benadryl may cause memory loss or dementia. Although rare, this side effect may be more common in older adults or people whove taken the drug long term. Symptoms can include:
- trouble speaking or finding the right words to say
- trouble concentrating
What might help
If youre experiencing memory loss or dementia while taking Benadryl, talk with your doctor. Theyll likely suggest that you stop taking Benadryl. Theyll also look for the cause of your memory loss or dementia so that they can recommend the right treatment for you.
Two Studies: Cbd Reduces Heart Inflammation
In this 2013 review of several studies , CBD was found to positively influence white blood cell survival and migration related to heart disease. The researchers concluded that A common theme throughout these studies is the anti-inflammatory and antioxidant effect of CBD. In the heart, in vivo CBD treatment protects against ischaemia-reperfusion damage and against cardiomyopathy associated with diabetes.
The second 2016 study published in the Journal of Molecular Medicine CBD reduced markers of inflammation in individuals with autoimmune myocarditis, a condition which causes inflammation of the heart.;
So, while its far too early to determine how exactly CBD influences cardiovascular function, there is promising evidence that CBDs known anti-inflammatory properties apply to the heart as well, and that CBD can potentially reduce heart-related inflammation.
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Whats The Difference Between First
Just like the name implies, the first generation antihistamine were the first type approved by the Food and Drug Administration . They began to be approved in the United States in the 1930s and are still prescribed today.
They work on histamine receptor in the brain and spinal cord along with other types of receptors. Most notable about this generation of antihistamines is that they cross the blood-brain barrier, which results in drowsiness.
Second-generation antihistamines were approved by the FDA and first came to market in the 1980s. The second-generation antihistamines do not cross the blood-brain barrier to the extent that first-generation do and therefore do not cause drowsiness at standard dosage levels. Second-generation antihistamines are considered to be safer than first generation antihistamines because they dont cause drowsiness and interact with fewer drugs.
Detection In Body Fluids
Diphenhydramine can be quantified in blood, plasma, or serum.Gas chromatography with mass spectrometry can be used with electron ionization on full scan mode as a screening test. GC-MS or GC-NDP can be used for quantification. Rapid urine drug screens using immunoassays based on the principle of competitive binding may show false-positive methadone results for people having ingested diphenhydramine. Quantification can be used to monitor therapy, confirm a diagnosis of poisoning in people who are hospitalized, provide evidence in an impaired driving arrest, or assist in a death investigation.
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Does Cbd Only Affect Heart Rate In Stressful Conditions
This suggests that CBD may only reduce heart rate if heart rate has otherwise been increased by; stressful conditions. This makes sense because increased heart rate and blood pressure is a result of autonomic arousal, aka the fight or flight response that is activated upon stress. Autonomic arousal is also the mechanism behind anxiety and panic attacks, and CBD is well-known as an effective anxiety reliever: one 2019 study in The Permanente Journal and another in the Journal of Neurotherapeutics both found that CBD reduced anxiety.;
So, CBD anxiolytic effects are likely related to its potential ability to reduce heart rate.;
Is Diphenhydramine Safe To Take If I’m Pregnant Or Breastfeeding
Diphenhydramine has not been adequately evaluated in pregnant women. It should be used only if the benefit outweighs the potential but unknown risks.
NURSING MOTHERS: Diphenhydramine is secreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature infants, antihistamines should not be used by nursing mothers.
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Possible Benadryl Side Effects
The following are some known Benadryl side effects. Keep in mind that the actual side effects will differ from person to person. Some individuals may as well suffer certain side effects which are not necessarily listed here. Whether the side effects are mild or severe will depend on the dosage taken and other factors that may or maybe unknown.
Test : Resting Heart Rate
This is the simplest test we conducted: each day over a period of three days, at the same time each day, we measured my heart rate without CBD, and then I took a 40mg dose of NuLeaf Naturals organic full-spectrum CBD oil, we waited 30 minutes, and we measured my heart rate again. We then took the average of all three measurements. Here are the results:
As you can see, I did experience a modest reduction in heart rate after taking the CBD, though the reduction wasnt consistent and it wasnt outside the normal variation in my heart rate.;
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